Bepridil free base
| Code | Size | Price |
|---|
| TAR-T5391L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T5391L-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T5391L-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Bepridil is a class IV anti-arrhythmic agent and calcium antagonist. Bepridil hydrochloride blocks calcium entry through membranous calcium channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arterioles.
CAS:
64706-54-3
Formula:
C24H34N2O
Molecular Weight:
366.549
Purity:
0.98
SMILES:
CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
References
Aprahamian ML, Tikunova SB, Price MV, Cuesta AF, Davis JP, Lindert S. Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. J Chem Inf Model. 2017 Dec 26;57(12):3056-3069. doi: 10.1021/acs.jcim.7b00536. Epub 2017 Nov 16. PubMed PMID: 29144742; PubMed Central PMCID: PMC5743627.
Abbate E, Boulakia M, Coudi?re Y, Gerbeau JF, Zitoun P, Zemzemi N. In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modeling and numerical simulations. J Pharmacol Toxicol Methods. 2018 Jan - Feb;89:59-72. doi: 10.1016/j.vascn.2017.10.005. Epub 2017 Oct 21. PubMed PMID: 29066291.
Sheng J, Tran PN, Li Z, Dutta S, Chang K, Colatsky T, Wu WW. Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity. J Pharmacol Toxicol Methods. 2017 Nov - Dec;88(Pt 2):109-122. doi: 10.1016/j.vascn.2017.08.006. Epub 2017 Aug 19. PubMed PMID: 28830713.
Ren J, Zhao Y, Fry EE, Stuart DI. Target identification and mode of action of four chemically divergent drugs against Ebola virus infection. J Med Chem. 2017 Dec 22. doi: 10.1021/acs.jmedchem.7b01249. [Epub ahead of print] PubMed PMID: 29272110.