TargetMol

Isofraxidin

Product Code:
 
TAR-T5S0045
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5S0045-5mg5mg£109.00
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TAR-T5S0045-10mg10mg£136.00
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TAR-T5S0045-25mg25mg£205.00
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TAR-T5S0045-50mg50mg£273.00
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TAR-T5S0045-100mg100mg£374.00
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Further Information

Bioactivity:
1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
CAS:
486-21-5
Formula:
C11H10O5
Molecular Weight:
222.196
Pathway:
Immunology/Inflammation; Proteases/Proteasome; MAPK; Neuroscience
Purity:
0.997
SMILES:
COc1cc2ccc(=O)oc2c(OC)c1O
Target:
MMP; ERK; p38 MAPK; TLR; COX

References

Yamazaki T , Tokiwa T . Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.[J]. Biological & Pharmaceutical Bulletin, 2010, 33(10):1716.