TargetMol

Peimisine

Product Code:
 
TAR-T5S0106
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5S0106-1mg1mg£119.00
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TAR-T5S0106-5mg5mg£182.00
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TAR-T5S0106-1mL1 mL * 10 mM (in DMSO)£214.00
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TAR-T5S0106-10mg10mg£230.00
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TAR-T5S0106-25mg25mg£343.00
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TAR-T5S0106-50mg50mg£468.00
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TAR-T5S0106-100mg100mg£661.00
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Further Information

Bioactivity:
1. Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Peimisine can attenuate lung tissue injury( ALI), LDH and MDA amount in ALI mice in a dose dependent manner, it also lower the total protein, total white blood cells, lymphocyte and neutrophilic leukocyte in bronchoalveolar lavage fluid( BALF); suggests that peimisine can play a protective role against LPS-induced acute lung injury. 3. Peimisine has the protective effect on the experimental hepatic fibrosis formation, the possible mechanisms are associated with inhibiting fibrogenesis and fibrosis accumulation, and decreasing lipid peroxidation. 4. Peimisine can inhibit angiotensin I converting enzyme activity in a dose-dependent manner, displaying 5 % inhibitory concentration values of 526.5 microM, thus, it may have antihypertensive action.
CAS:
19773-24-1
Formula:
C27H41NO3
Molecular Weight:
427.629
Pathway:
Endocrinology/Hormones; Neuroscience
Purity:
0.998
SMILES:
C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
Target:
RAAS; AChR

References

Shim K S, Gu D R, Hwang Y H, et al. Water Extract of Fritillariae thunbergii Bulbus Inhibits RANKL-Mediated Osteoclastogenesis and Ovariectomy-Induced Trabecular Bone Loss. Molecules. 2022, 27(1): 169. Liu J , Xu X F , Guo C Y , et al. Protection of peimisine on hepatic fibrosis of rats induced by CCl4[J]. Chinese Traditional & Herbal Drugs, 2013, 44(11):1455-1459.