TargetMol

Desmethoxyyangonin

Product Code:
 
TAR-T5S0734
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5S0734-1mg1mg£119.00
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TAR-T5S0734-1mL1 mL * 10 mM (in DMSO)£184.00
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TAR-T5S0734-5mg5mg£185.00
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TAR-T5S0734-10mg10mg£230.00
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TAR-T5S0734-25mg25mg£350.00
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TAR-T5S0734-50mg50mg£487.00
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Further Information

Bioactivity:
1. Desmethoxy yangonin protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.
CAS:
15345-89-8
Formula:
C14H12O3
Molecular Weight:
228.247
Pathway:
; Neuroscience
Purity:
0.9929
SMILES:
COc1cc(C=Cc2ccccc2)oc(=O)c1
Target:
Monoamine Oxidase

References

Ma Y , Sachdeva K , Liu J , et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2004, 32(11):1317.