PHA-665752
Code | Size | Price |
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TAR-T6128-5mg | 5mg | £118.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6128-1mL | 1 mL * 10 mM (in DMSO) | £139.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6128-10mg | 10mg | £145.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6128-25mg | 25mg | £222.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6128-50mg | 50mg | £306.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6128-100mg | 100mg | £462.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.
CAS:
477575-56-7
Formula:
C32H34Cl2N4O4S
Molecular Weight:
641.61
Pathway:
Angiogenesis; Cytoskeletal Signaling; Autophagy; Tyrosine Kinase/Adaptors; Apoptosis
Purity:
0.9935
SMILES:
Cc1[nH]c(C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1
Target:
Apoptosis; VEGFR; FGFR; c-Met/HGFR; Bcr-Abl; Autophagy
References
Yuan S, Gong Y, Chen R, et al. Chinese herbal formula QHF inhibits hepatocellular carcinoma metastasis via HGF/c-Met signaling pathway. Biomedicine & Pharmacotherapy. 2020, 132: 110867.
Christensen JG, et al. Cancer Res, 2003, 63(21), 7345-7355.
Ma PC, et al. Clin Cancer Res, 2005, 11(6), 2312-2319.
Puri N, et al. Cancer Res, 2007, 67(8), 3529-3534.