Canertinib

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TargetMol
Product Code: TAR-T6136
Supplier: TargetMol
CodeSizePrice
TAR-T6136-5mg5mg£95.00
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Quantity:
TAR-T6136-1mL1 mL * 10 mM (in DMSO)£97.00
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Quantity:
TAR-T6136-10mg10mg£111.00
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Quantity:
TAR-T6136-25mg25mg£122.00
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Quantity:
TAR-T6136-50mg50mg£134.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Canertinib is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hypoxia as determined by PET.
CAS:
267243-28-7
Formula:
C24H25ClFN5O3
Molecular Weight:
485.94
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.99
SMILES:
Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
Target:
EGFR

References

Slichenmyer WJ et al. Semin Oncol. 2001; 28(5 Suppl 16): 80-85. Smaill JB et al. J Med Chem. 2000; 43(7): 1380-1397. Nelson JM et al. J Biol Chem. 2001; 276(18): 14842-14827. Hughes DP et al. Pediatr Blood Cancer. 2006; 46(5): 614-623. Citri A et al. EMBO J. 2002; 21(10): 2407-2417.