Nortadalafil

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TargetMol
Product Code: TAR-T6147
Supplier: TargetMol
CodeSizePrice
TAR-T6147-1mg1mg£95.00
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TAR-T6147-2mg2mg£106.00
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TAR-T6147-5mg5mg£128.00
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TAR-T6147-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T6147-10mg10mg£161.00
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TAR-T6147-25mg25mg£242.00
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TAR-T6147-50mg50mg£369.00
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TAR-T6147-100mg100mg£550.00
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TAR-T6147-200mg200mg£751.00
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TAR-T6147-500mg500mg£1,083.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.
CAS:
171596-36-4
Formula:
C21H17N3O4
Molecular Weight:
375.384
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C1CNC(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Target:
PDE

References

Daugan A . The Discovery of Tadalafil : A Novel and Highly Selective PDE5 Inhibitor. 2:2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Analogues[J]. J. Med. Chem. 2003, 46. Takahiro R , Nakamura S , Kohno H , et al. Contribution of CYP3A Isoforms to Dealkylation of PDE5 Inhibitors: A Comparison between Sildenafil N-Demethylation and Tadalafil Demethylenation[J]. Biological & Pharmaceutical Bulletin, 2015, 38(1):58-65.