TargetMol

PF-562271 besylate

Product Code:
 
TAR-T6177
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6177-1mg1mg£113.00
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TAR-T6177-2mg2mg£130.00
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TAR-T6177-5mg5mg£167.00
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TAR-T6177-10mg10mg£191.00
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TAR-T6177-1mL1 mL * 10 mM (in DMSO)£199.00
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TAR-T6177-25mg25mg£270.00
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TAR-T6177-50mg50mg£367.00
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TAR-T6177-100mg100mg£511.00
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Further Information

Bioactivity:
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
CAS:
939791-38-5
Formula:
C27H26F3N7O6S2
Molecular Weight:
665.66
Pathway:
Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint
Purity:
0.995
SMILES:
OS(=O)(=O)c1ccccc1.CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
Target:
FAK; PYK2; CDK

References

Bagi CM, et al. Cancer Biol Ther. 2009, 8(9), 856-865. Serrels A, et al. Int J Cancer. 2012, 131(2), 287-297. Sun H, et al. Cancer Biol Ther. 2010, 10(1), 38-43. Roberts WG, et al. Cancer Res. 2008, 68(6), 1935-1944.