WZ4002

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TargetMol
Product Code: TAR-T6238
Supplier: TargetMol
CodeSizePrice
TAR-T6238-5mg5mg£107.00
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Quantity:
TAR-T6238-1mL1 mL * 10 mM (in DMSO)£112.00
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Quantity:
TAR-T6238-10mg10mg£124.00
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Quantity:
TAR-T6238-25mg25mg£166.00
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Quantity:
TAR-T6238-50mg50mg£229.00
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Quantity:
TAR-T6238-100mg100mg£349.00
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Quantity:
TAR-T6238-200mg200mg£485.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.
CAS:
1213269-23-8
Formula:
C25H27ClN6O3
Molecular Weight:
494.97
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9812
SMILES:
O=C(C=C)NC=1C=CC=C(OC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCN(C)CC4)C1
Target:
EGFR

References

Sakuma Y, et al. Lab Invest. 2012, 92(3), 371-383. Zannetti A, et al. J Nucl Med. 2012, 53(3), 443-450. Zhou W, et al. Nature. 2009, 462(7276), 1070-1074.