Amonafide

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TargetMol
Product Code: TAR-T6336
Supplier: TargetMol
CodeSizePrice
TAR-T6336-1mg1mg£97.00
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TAR-T6336-2mg2mg£108.00
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TAR-T6336-5mg5mg£129.00
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TAR-T6336-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T6336-10mg10mg£142.00
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TAR-T6336-25mg25mg£204.00
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TAR-T6336-50mg50mg£308.00
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TAR-T6336-100mg100mg£465.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
CAS:
69408-81-7
Formula:
C16H17N3O2
Molecular Weight:
283.331
Pathway:
DNA Damage/DNA Repair
Purity:
0.98
SMILES:
CN(C)CCN1C(=O)c2cccc3cc(N)cc(C1=O)c23
Target:
Topoisomerase

References

Bra?aMF, et al. J Med Chem, 2004, 47(6), 1391-1399. Andersson BS, et al. Cancer Res, 1987, 47(4), 1040-1044. De Isabella P, Nucleic Acids Res, 1995, 23(2), 223-229. Wang H, et al. J Biol Chem, 2001, 276(19), 151990-151995. Hsiang YH, et al. Mol Pharmacol, 1989, 36(3), 371-376.