Ferrostatin-1
| Code | Size | Price |
|---|
| TAR-T6500-5mg | 5mg | £118.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6500-1mL | 1 mL * 10 mM (in DMSO) | £123.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6500-10mg | 10mg | £142.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6500-25mg | 25mg | £222.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6500-50mg | 50mg | £335.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6500-200mg | 200mg | £519.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6500-500mg | 500mg | £791.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ferrostatin-1 is a potent ferroptosis inhibitor (EC50: 60 nM).
Biological Applications:
Ferrostatin-1 and Deferoxamine mesylate, as inhibitors of ferroptosis, play crucial roles in regulating this iron-dependent form of cell death. Ferrostatin-1 regulates ferroptosis by influencing lipid peroxidation and iron metabolism, while Deferoxamine mesylate not only inhibits ferroptosis but also exhibits excellent antioxidant, anti-proliferative, and anti-tumor activities. Therefore, Deferoxamine mesylate is applicable to research in diabetes, neurodegenerative diseases, as well as in anti-cancer and anti-COVID-19 studies. Abundant research indicates that modulating ferroptosis is pivotal in tumor suppression, immunity, neurodegenerative diseases, tissue and organ damage, as well as various inflammatory and infectious diseases.
CAS:
347174-05-4
Description:
Ferrostatin-1 is a potent ferroptosis inhibitor (EC50: 60 nM).
Formula:
C15H22N2O2
Mechanism of Action:
Ferroptosis is a form of regulated cell death primarily caused by iron-dependent oxidative damage. Under physiological conditions, iron levels in cells are in dynamic equilibrium. Excessive iron ions can lead to cellular iron overload, characterized by the deposition of iron ions causing lipid peroxidation reactions and the accumulation of reactive oxygen species (ROS) generated by iron metabolism. Ultimately, this results in cell death.
Ferroptosis can be inhibited by various small molecules, including Ferrostatin-1 and Deferoxamine mesylate. Ferrostatin-1, an antioxidant, inhibits cell ferroptosis by inducing the disappearance of lipid hydroperoxides through the generation of an anti-ferroptotic effect. Deferoxamine mesylate, on the other hand, is an iron-chelating agent that binds to iron ions, reducing the accumulation and deposition of iron in tissues and suppressing cell ferroptosis.
Molecular Weight:
262.353
Pathway:
Cell Cycle/Checkpoint; Apoptosis; Microbiology/Virology
Purity:
0.9951
Research Area:
Tumour; Oesophageal Cancer; Tumour Immunology; Diabetes; Kidney Disease; Pathobiology; Epidemiology; Immunology; Research on molecular mechanisms
SMILES:
CCOC(=O)c1ccc(NC2CCCCC2)c(N)c1
Target:
Ferroptosis; Antifungal
References
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