Raltitrexed
Code | Size | Price |
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TAR-T6632-5mg | 5mg | £98.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-1mL | 1 mL * 10 mM (in DMSO) | £101.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-10mg | 10mg | £108.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-25mg | 25mg | £142.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-50mg | 50mg | £197.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-100mg | 100mg | £306.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-200mg | 200mg | £468.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6632-500mg | 500mg | £699.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Raltitrexed?IC50 of 9 nM?, a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
CAS:
112887-68-0
Formula:
C21H22N4O6S
Molecular Weight:
458.49
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9906
SMILES:
CN(Cc1ccc2[nH]c(C)nc(=O)c2c1)c1ccc(s1)C(=O)NC(CCC(O)=O)C(O)=O
Target:
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis
References
Aschele C, et al. Clin Cancer Res, 1998, 4(5), 1323-1330.
Van Cutsem E, et al. Ann Oncol, 2002, 13(4), 513-522.
Wang D, et al. Cancer Chemother Pharmacol, 2006, 57(1), 97-104.
Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398(1-2):223-31.
Di Gennaro E, et al. Cancer Biol Ther, 2009, 8(9), 782-791.
Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23(5):237-48
Peters GJ, et al. Eur J Cancer, 2000, 36(7), 916-924.