Sabutoclax
Code | Size | Price |
---|
TAR-T6650-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6650-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
CAS:
1228108-65-3
Formula:
C42H40N2O8
Molecular Weight:
700.788
Pathway:
Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
Purity:
0.98
SMILES:
C[C@@H](CNC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NC[C@H](C)c3ccccc3)c(O)c(O)cc2c1O)c1ccccc1
Target:
BCL; Bcr-Abl
References
Wei J, et al. J Med Chem, 2010, 53(10), 4166-4176
Dash R, et al. Proc Natl Acad Sci U S A, 2011, 108(21), 8785-8790.