TargetMol

SKI II

Product Code:
 
TAR-T6673
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T6673-5mg5mg£102.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-1mL1 mL * 10 mM (in DMSO)£113.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-10mg10mg£116.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-25mg25mg£157.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-50mg50mg£221.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-100mg100mg£333.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-200mg200mg£544.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6673-500mg500mg£828.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
CAS:
312636-16-1
Formula:
C15H11ClN2OS
Molecular Weight:
302.78
Pathway:
Apoptosis; GPCR/G Protein; Stem Cells; Cytoskeletal Signaling
Purity:
0.9997
SMILES:
Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1
Target:
Apoptosis; Wnt/beta-catenin; S1P Receptor

References

Chiba Y, et al. J Pharmacol Sci, 2010, 114(3), 304-310. Zhu ZA, et al. Asian Pac J Cancer Prev, 2012, 13(2), 625-631. Liu H, et al. SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/?-catenin signaling pathway. Life Sci. 2016 Apr 15;151:23-9. French KJ, et al. Cancer Res, 2003, 63(18), 5962-5969. French KJ, et al. J Pharmacol Exp Ther, 2006, 318(2), 596-603.