SKI II

TargetMol
Product Code: TAR-T6673
Supplier: TargetMol
CodeSizePrice
TAR-T6673-5mg5mg£102.00
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TAR-T6673-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T6673-10mg10mg£116.00
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TAR-T6673-25mg25mg£157.00
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TAR-T6673-50mg50mg£221.00
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TAR-T6673-100mg100mg£333.00
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TAR-T6673-200mg200mg£544.00
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TAR-T6673-500mg500mg£828.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
CAS:
312636-16-1
Formula:
C15H11ClN2OS
Molecular Weight:
302.78
Pathway:
Apoptosis; GPCR/G Protein; Stem Cells; Cytoskeletal Signaling
Purity:
0.9997
SMILES:
Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1
Target:
Apoptosis; Wnt/beta-catenin; S1P Receptor

References

Chiba Y, et al. J Pharmacol Sci, 2010, 114(3), 304-310. Zhu ZA, et al. Asian Pac J Cancer Prev, 2012, 13(2), 625-631. Liu H, et al. SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/?-catenin signaling pathway. Life Sci. 2016 Apr 15;151:23-9. French KJ, et al. Cancer Res, 2003, 63(18), 5962-5969. French KJ, et al. J Pharmacol Exp Ther, 2006, 318(2), 596-603.