Tyrphostin AG 879
Code | Size | Price |
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TAR-T6712-5mg | 5mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6712-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6712-10mg | 10mg | £125.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6712-25mg | 25mg | £197.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6712-50mg | 50mg | £282.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6712-100mg | 100mg | £432.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
CAS:
148741-30-4
Formula:
C18H24N2OS
Molecular Weight:
316.46
Pathway:
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Apoptosis
Purity:
0.98
SMILES:
CC(C)(C)c1cc(C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
Target:
Apoptosis; EGFR; Trk receptor; HER; PDGFR
References
Rende M, et al. Anticancer Drugs, 2006, 17(8), 929-941.
Zhou Y, et al. Cancer Res, 2005, 65(13), 5848-5856.
Larsson LI, et al. Cell Mol Life Sci, 2004, 61(19-20), 2624-2631.
He H, et al. Cancer J, 2001, 7(3), 191-202.
Zhou Y et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11.
He H, et al. Cancer Biol Ther, 2004, 3(1), 96-101.