VU0361737

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TargetMol
Product Code: TAR-T6726
Supplier: TargetMol
CodeSizePrice
TAR-T6726-5mg5mg£108.00
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Quantity:
TAR-T6726-1mL1 mL * 10 mM (in DMSO)£112.00
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Quantity:
TAR-T6726-10mg10mg£124.00
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Quantity:
TAR-T6726-25mg25mg£173.00
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Quantity:
TAR-T6726-50mg50mg£241.00
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Quantity:
TAR-T6726-100mg100mg£381.00
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Quantity:
TAR-T6726-500mg500mg£791.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity at mGlu5 and mGlu8 receptors, and is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.
CAS:
1161205-04-4
Formula:
C13H11ClN2O2
Molecular Weight:
262.69
Pathway:
Neuroscience
Purity:
0.9986
SMILES:
COc1cc(NC(=O)c2ccccn2)ccc1Cl
Target:
GluR

References

Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118. Engers DW, et al. J Med Chem, 2011, 54(4), 1106-1110.