AS1842856

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TargetMol
Product Code: TAR-T6762
Supplier: TargetMol
CodeSizePrice
TAR-T6762-5mg5mg£108.00
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Quantity:
TAR-T6762-1mL1 mL * 10 mM (in DMSO)£112.00
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Quantity:
TAR-T6762-10mg10mg£124.00
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Quantity:
TAR-T6762-25mg25mg£158.00
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Quantity:
TAR-T6762-50mg50mg£195.00
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Quantity:
TAR-T6762-100mg100mg£262.00
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Quantity:
TAR-T6762-200mg200mg£353.00
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Quantity:
TAR-T6762-500mg500mg£548.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
CAS:
836620-48-5
Formula:
C18H22FN3O3
Molecular Weight:
347.39
Pathway:
Autophagy; Apoptosis
Purity:
0.9956
SMILES:
CCn1cc(C(O)=O)c(=O)c2c(N)c(F)c(NC3CCCCC3)cc12
Target:
Autophagy; FOXO1

References

Lu Y, Huang R, Sun Z, et al.A bovine milk-derived peptide ameliorates pancreatic ?-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes.Food & Function.2023 Peng Zou, et al. Cell Cycle. 2014 Dec 1; 13(23): 3759?3767. Takeyuki Nagashima,et al.Mol Pharmacol.2010,78(5):961-970.