Riociguat

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TargetMol
Product Code: TAR-T6968
Supplier: TargetMol
CodeSizePrice
TAR-T6968-5mg5mg£119.00
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Quantity:
TAR-T6968-1mL1 mL * 10 mM (in DMSO)£121.00
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Quantity:
TAR-T6968-10mg10mg£148.00
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Quantity:
TAR-T6968-25mg25mg£204.00
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Quantity:
TAR-T6968-50mg50mg£273.00
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Quantity:
TAR-T6968-100mg100mg£417.00
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Quantity:
TAR-T6968-500mg500mg£859.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
CAS:
625115-55-1
Formula:
C20H19FN8O2
Molecular Weight:
422.424
Pathway:
GPCR/G Protein
Purity:
0.9995
SMILES:
COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12
Target:
Guanylate cyclase

References

Reiss C, et al. Br J Pharmacol. 2015, 172(21), 5199-5210. Reinke Y, et al. Eur J Pharmacol. 2015, 767, 1-9. Liu R, Kang Y, Chen L. Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nature Communications. 2021, 12(1): 1-10. Schermuly RT, et al. Eur Respir J. 2008, 32(4), 881-891.