TargetMol

Oroxylin A

Product Code:
 
TAR-T6S1315
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T6S1315-1mL1 mL * 10 mM (in DMSO)£135.00
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TAR-T6S1315-20mg20mg£183.00
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Further Information

Bioactivity:
1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.
CAS:
480-11-5
Formula:
C16H12O5
Molecular Weight:
284.267
Pathway:
Autophagy; Chromatin/Epigenetic; Microbiology/Virology; Metabolism
Purity:
0.9967
SMILES:
COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1
Target:
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy

References

Ku S K , Lee I C , Bae J S . Antithrombotic activities of oroxylin A in vitro and in vivo[J]. Archives of Pharmacal Research, 2013, 37(5):679-86. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. European Journal of Pharmaceutical Sciences. 2021: 105786. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786. Ni Z, Ma H, Li X, et al.Wogonin alleviates BaP?induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression.Environmental Toxicology.2023