Necrosulfonamide

TargetMol
Product Code: TAR-T7129
Supplier: TargetMol
CodeSizePrice
TAR-T7129-5mg5mg£111.00
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Quantity:
TAR-T7129-1mL1 mL * 10 mM (in DMSO)£125.00
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Quantity:
TAR-T7129-10mg10mg£128.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7129-25mg25mg£167.00
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Quantity:
TAR-T7129-50mg50mg£235.00
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Quantity:
TAR-T7129-100mg100mg£318.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Necrosulfonamide is a novel inhibitor of MLKL.
CAS:
432531-71-0
Formula:
C18H15N5O6S2
Molecular Weight:
461.47
Pathway:
MAPK
Purity:
0.98
SMILES:
COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)C=Cc2ccc(s2)[N+]([O-])=O)cc1
Target:
MLK

References

Chen C, Cheng Y, Lei H, et al.SHP2 potentiates anti-PD-1 effectiveness through intervening cell pyroptosis resistance in triple-negative breast cancer.Biomedicine & Pharmacotherapy.2023, 168: 115797. Li Y, Hu G, Huang F, et al.MAT1A Suppression by the CTBP1/HDAC1/HDAC2 Transcriptional Complex Induces Immune Escape and Reduces Ferroptosis in Hepatocellular Carcinoma.Laboratory Investigation.2023, 103(8): 100180. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977. Menacher G , Balszuweit F , Lang S , et al. Necrosulfonamide ? Unexpected effect in the course of a sulfur mustard intoxication[J]. Chemico-Biological Interactions, 2018. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells[J]. Molecular Neurobiology. 2020, 57(11): 4628-4641. Yi Y, Gao K, Zhang L, et al. Zearalenone Induces MLKL-Dependent Necroptosis in Goat Endometrial Stromal Cells via the Calcium Overload/ROS Pathway. International Journal of Molecular Sciences. 2022, 23(17): 10170. Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 Wang Y , Wang J , Wang H , et al. Necrosulfonamide Attenuates the Spinal Cord Injury Via Necroptosis Inhibition[J]. World Neurosurgery, 2018:S1878875018306569. Yi Y, Gao K, Lin P, et al. Staphylococcus aureus-Induced Necroptosis Promotes Mitochondrial Damage in Goat Endometrial Epithelial Cells. Animals. 2022, 12(17): 2218. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells. Molecular Neurobiology. 2020, 57(11): 4628-4641.