Fadrozole HCl hydrate
| Code | Size | Price |
|---|
| TAR-T7197L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7197L-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7197L-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer.
CAS:
176702-70-8
Formula:
C28H30Cl2N6O
Molecular Weight:
537.49
Purity:
0.98
SMILES:
O.Cl.Cl.N#Cc1ccc(cc1)C1CCCc2cncn12.N#Cc1ccc(cc1)C1CCCc2cncn12
References
Brixius-Anderko S, Scott EE. Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design. J Biol Chem. 2018 Nov 13. pii: jbc.RA118.006214. doi: 10.1074/jbc.RA118.006214. [Epub ahead of print] PubMed PMID: 30425102.
Schroeder AL, Ankley GT, Habib T, Garcia-Reyero N, Escalon BL, Jensen KM, Kahl MD, Durhan EJ, Makynen EA, Cavallin JE, Martinovic-Weigelt D, Perkins EJ, Villeneuve DL. Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas). Gen Comp Endocrinol. 2017 Oct 1;252:79-87. doi: 10.1016/j.ygcen.2017.07.022. Epub 2017 Jul 21. PubMed PMID: 28736226; PubMed Central PMCID: PMC6010346.
Hajihoseini Z, Eghbalsaied S. Simultaneous effects of IGF1 and Fadrozole on parthenogenesis and pluripotency markers in chicken embryo. Theriogenology. 2018 Jul 1;114:317-323. doi: 10.1016/j.theriogenology.2018.04.009. Epub 2018 Apr 13. PubMed PMID: 29684809.
Luzio A, Matos M, Santos D, Fonta?nhas-Fernandes AA, Monteiro SM, Coimbra AM. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17?-ethinylestradiol and fadrozole exposures. Aquat Toxicol. 2016 Aug;177:269-84. doi: 10.1016/j.aquatox.2016.05.029. Epub 2016 Jun 3. PubMed PMID: 27337697.