2-Iminobiotin
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| TAR-T7206-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T7206-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).
CAS:
13395-35-2
Formula:
C10H17N3O2S
Molecular Weight:
243.33
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
NC1=N[C@H]2CS[C@@H](CCCCC(O)=O)[C@H]2N1
Target:
NOS; NO Synthase
References
Sup S J , Green B G , Grant S K . 2-Iminobiotin Is an Inhibitor of Nitric Oxide Synthases[J]. Biochemical & Biophysical Research Communications, 1994, 204(2):0-968.
Zitta K , Peeters-Scholte C , Sommer L , et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study[J]. Frontiers in Pharmacology, 2018, 8:971.