TargetMol

2-Iminobiotin

Product Code:
 
TAR-T7206
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).
CAS:
13395-35-2
Formula:
C10H17N3O2S
Molecular Weight:
243.33
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
NC1=N[C@H]2CS[C@@H](CCCCC(O)=O)[C@H]2N1
Target:
NOS; NO Synthase

References

Sup S J , Green B G , Grant S K . 2-Iminobiotin Is an Inhibitor of Nitric Oxide Synthases[J]. Biochemical & Biophysical Research Communications, 1994, 204(2):0-968. Zitta K , Peeters-Scholte C , Sommer L , et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study[J]. Frontiers in Pharmacology, 2018, 8:971.