Grp94 Inhibitor-1
Code | Size | Price |
---|
TAR-T7261-5mg | 5mg | £103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7261-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7261-10mg | 10mg | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7261-25mg | 25mg | £168.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7261-50mg | 50mg | £229.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7261-100mg | 100mg | £344.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).
CAS:
2234897-35-7
Formula:
C22H28N2O2
Molecular Weight:
352.478
Pathway:
Endocrinology/Hormones; Cytoskeletal Signaling; GPCR/G Protein; Metabolism
Purity:
0.98
SMILES:
CC(C)c1ccc(cc1)-c1ccc(N[C@H]2CC[C@H](O)CC2)c(c1)C(N)=O
Target:
GPR; HSP
References
Lu Y, Li D, Ai H, et al.Glucose-regulated protein 94 facilitates the proliferation of the Bombyx mori nucleopolyhedrovirus via inhibiting apoptosis.International Journal of Biological Macromolecules.2023: 127158.
Hao M, Guo Y, Zhang Z, et al. 6-acrylic phenethyl ester-2-pyranone derivative induces apoptosis and G2/ M arrest by targeting GRP94 in colorectal cancer. Bioorganic Chemistry. 2022, 123: 105802
Jiang F , Guo A P , Xu J C , et al. Discovery of a Potent Grp94 Selective Inhibitor with Anti-inflammatory Efficacy in a Mouse Model of Ulcerative Colitis[J]. Journal of Medicinal Chemistry, 2018.