DPN
Code | Size | Price |
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TAR-T7644-5mg | 5mg | £96.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7644-10mg | 10mg | £112.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7644-1mL | 1 mL * 10 mM (in DMSO) | £117.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7644-25mg | 25mg | £157.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7644-50mg | 50mg | £230.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7644-100mg | 100mg | £353.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
DPN is an selective agonist of estrogen receptor β (ERβ) .
CAS:
1428-67-7
Formula:
C15H13NO2
Molecular Weight:
239.274
Pathway:
Autophagy; Endocrinology/Hormones; Apoptosis
Purity:
0.9885
SMILES:
Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
Target:
Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy
References
Marvin, J, Meyers, et al. Estrogen Receptor-? Potency-Selective Ligands:? Structure?Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues[J]. Journal of Medicinal Chemistry, 2001.
Lu Z, Cao Y, Zhang D, et al. Discovery of Thieno [2, 3-e] indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability. Journal of Medicinal Chemistry. 2022
Huang S Y , Xin H , Sun J , et al. Estrogen receptor ? agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor ?B activation[J]. Fertility and Sterility, 2013, 100(1):234-240.