Aminopterin sodium
| Code | Size | Price |
|---|
| TAR-T7730L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7730L-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7730L-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis.
CAS:
58602-66-7
Formula:
C19H19N8NaO5
Molecular Weight:
462.402
Purity:
0.98
SMILES:
[Na+].Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C([O-])=O)cnc2n1
References
Fu LP. Therapeutic approach for the cesarean scar pregnancy. Medicine (Baltimore). 2018 May;97(18):e0476. doi: 10.1097/MD.0000000000010476. PubMed PMID: 29718837.
Del Rosario M, Tsai H, Dasanu CA. Durable Complete Response of Primary CNS Lymphoma in an 80-Year-Old Patient with Retroviral Infection. Conn Med. 2017 Apr;81(4):223-226. PubMed PMID: 29714407.
Ren Z, Yu L, Xie M, Liang Y, Zhu F, Huang R, Zhang Z, Fu C. Successful treatment of multisite hemorrhage by several methods in brain metastasis of choriocarcinoma: A case report. Medicine (Baltimore). 2018 May;97(21):e10794. doi: 10.1097/MD.0000000000010794. PubMed PMID: 29794762.
Tobias AM, Toska D, Lange K, Eck T, Bhat R, Janson CA, Rotella DP, Gubler U, Goodey NM. Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti. PLoS One. 2018 May 22;13(5):e0197173. doi: 10.1371/journal.pone.0197173. eCollection 2018. PubMed PMID: 29787565; PubMed Central PMCID: PMC5963757.