SNC 80
Code | Size | Price |
---|
TAR-T8414-1mg | 1mg | £99.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T8414-5mg | 5mg | £130.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T8414-10mg | 10mg | £169.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T8414-25mg | 25mg | £309.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T8414-50mg | 50mg | £405.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
SNC80 is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant?like effects. SNC80 has the potential for multiple headache disorders treatment.
CAS:
156727-74-1
Formula:
C28H39N3O2
Molecular Weight:
449.63
Pathway:
Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Purity:
0.9867
SMILES:
[C@H](N1[C@@H](C)CN(CC=C)[C@H](C)C1)(C2=CC(OC)=CC=C2)C3=CC=C(C(N(CC)CC)=O)C=C3
Target:
Opioid Receptor
References
Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66.
Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159.
Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr;148:77-86.
Metcalf MD, et al. The ? opioid receptor agonist SNC80 selectively activates heteromeric ?-? opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.
zinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37(14):2125-8.
ripps IJ, et al. Role of signalling molecules in behaviours mediated by the ? opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175(6):891-901.