MCI-225 hydrochloride hydrate
Code | Size | Price |
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TAR-T8443L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T8443L-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T8443L-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypometabolism. MCI-225 enhances attentional eye tracking in midpontine pretrigeminal preparation.
CAS:
476148-82-0
Formula:
C17H20ClFN4OS
Molecular Weight:
382.88
Purity:
0.98
SMILES:
O.Cl.Cc1cc2c(nc(nc2s1)N1CCNCC1)-c1ccccc1F
References
MCI 225. Drugs R D. 1999 Jul;2(1):51-2. PubMed PMID: 10610283.
Wu YL, Yoshida M, Emoto H, Ishii H, Koga K, Tanaka M. Effects of acute and chronic administration of MCI-225, a new selective noradrenaline reuptake inhibitor with 5-HT3 receptor blocking action, on extracellular noradrenaline levels in the hypothalamus of stressed rats. Jpn J Pharmacol. 2000 May;83(1):31-8. PubMed PMID: 10887938.
Ishigooka J. [Serotonin-noradrenaline reuptake inhibitors(SNRIs)]. Nihon Rinsho. 2001 Aug;59(8):1523-9. Review. Japanese. PubMed PMID: 11519152.
Eguchi J, Inomata Y, Saito K. The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. Pharmacol Biochem Behav. 2001 Apr;68(4):677-83. PubMed PMID: 11526964.