Dabrafenib Mesylate

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TargetMol
Product Code: TAR-T8474
Supplier: TargetMol
CodeSizePrice
TAR-T8474-5mg5mg£105.00
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TAR-T8474-1mL1 mL * 10 mM (in DMSO)£117.00
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Quantity:
TAR-T8474-10mg10mg£117.00
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Quantity:
TAR-T8474-25mg25mg£128.00
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Quantity:
TAR-T8474-50mg50mg£139.00
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Quantity:
TAR-T8474-100mg100mg£164.00
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TAR-T8474-500mg500mg£262.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
CAS:
1195768-06-9
Formula:
C24H24F3N5O5S3
Molecular Weight:
615.66
Pathway:
MAPK
Purity:
0.9945
SMILES:
CS(O)(=O)=O.CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Target:
Raf

References

Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9.