DOTMA

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TargetMol
Product Code: TAR-T8902
Supplier: TargetMol
CodeSizePrice
TAR-T8902-5mg5mg£100.00
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TAR-T8902-10mg10mg£113.00
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TAR-T8902-25mg25mg£142.00
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Quantity:
TAR-T8902-50mg50mg£195.00
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Quantity:
TAR-T8902-100mg100mg£303.00
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TAR-T8902-200mg200mg£414.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
DOTMA is a tetra-methylated DOTA analogue. DOTMA is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.
CAS:
104872-42-6
Formula:
C42H84ClNO2
Molecular Weight:
670.58
Purity:
0.9822
SMILES:
[Cl-].O(CCCCCCCCC=CCCCCCCCC)CC(OCCCCCCCCC=CCCCCCCCC)C[N+](C)(C)C

References

Aime S, et al. Properties, solution state behavior, and crystal structures of chelates of DOTMA. Inorg Chem. 2011;50(17):7955-7965. Ren T, et al. Structural basis of DOTMA for its high intravenous transfection activity in mouse. Gene Ther. 2000;7(9):764-768. Bhavsar D, et al. Translational siRNA therapeutics using liposomal carriers: prospects & challenges. Curr Gene Ther. 2012;12(4):315-332.