FR054

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TargetMol
Product Code: TAR-T9468
Supplier: TargetMol
CodeSizePrice
TAR-T9468-5mg5mg£102.00
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Quantity:
TAR-T9468-1mL1 mL * 10 mM (in DMSO)£105.00
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Quantity:
TAR-T9468-10mg10mg£118.00
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Quantity:
TAR-T9468-25mg25mg£146.00
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Quantity:
TAR-T9468-50mg50mg£173.00
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Quantity:
TAR-T9468-100mg100mg£230.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.
CAS:
35954-65-5
Formula:
C28H37N2O16
Molecular Weight:
657.6
Purity:
0.98
SMILES:
CC(OC[C@H]([C@H]1OC(C)=O)O[C@@H]2OC(C)=N[C@@H]2[C@H]1OC(C)=O)=OCC(OC[C@H]([C@H]1OC(C)=O)O[C@@H]2OC(C)=N[C@@H]2[C@H]1OC(C)=O)=O

References

Francesca Ricciardiello, et al.Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis.Cell Death Dis . 2018 Mar 7;9(3):377.