TargetMol

Tomatidine

Product Code:
 
TAR-TMA0507
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TMA0507-5mg5mg£104.00
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TAR-TMA0507-10mg10mg£117.00
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TAR-TMA0507-25mg25mg£163.00
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Further Information

Bioactivity:
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
CAS:
77-59-8
Formula:
C27H45NO2
Molecular Weight:
415.662
Pathway:
MAPK; Autophagy; NF-κb
Purity:
0.9998
SMILES:
[H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@]1(CC[C@H](C)CN1)O2
Target:
NF-κB; JNK; Autophagy

References

Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells. Antimicrob Agents Chemother. 2011 May;55(5):1937-45. Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression. Chem Biol Interact. 2013 May 25;203(3):580-7. Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus. Eur J Med Chem. 2014 Jun 10;80:605-20.