Ganoderic acid DM
Code | Size | Price |
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TAR-TN1663-5mg | 5mg | £304.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1663-1mL | 1 mL * 10 mM (in DMSO) | £673.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.
CAS:
173075-45-1
Formula:
C30H44O4
Molecular Weight:
468.678
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H][C@@]12CC(=O)C3=C(CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCC=C(/C)C(O)=O)[C@@]1(C)CCC(=O)C2(C)C
Target:
PARP; Androgen Receptor; CDK
References
Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.Fitoterapia. 2012 Mar;83(2):408-14.