TargetMol

Nortrachelogenin

Product Code:
 
TAR-TN4675
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN4675-1mg1mg£245.00
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TAR-TN4675-5mg5mg£504.00
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TAR-TN4675-1mL1 mL * 10 mM (in DMSO)£512.00
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TAR-TN4675-10mg10mg£696.00
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TAR-TN4675-25mg25mg£1,018.00
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TAR-TN4675-50mg50mg£1,372.00
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Further Information

Bioactivity:
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis.
CAS:
34444-37-6
Formula:
C20H22O7
Molecular Weight:
374.4
Pathway:
GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling; Cytoskeletal Signaling; NF-κb; Tyrosine Kinase/Adaptors; Immunology/Inflammation; Proteases/Proteasome; Microbiology/Virology; Apoptosis
Purity:
0.98
SMILES:
COc1cc(C[C@H]2COC(=O)[C@]2(O)Cc2ccc(O)c(OC)c2)ccc1O
Target:
IL Receptor; TNF; NOS; NF-κB; ROS; Akt; Caspase; COX; HIV Protease; IGF-1R; Prostaglandin Receptor; Antifection