TargetMol

Icariside E4

Product Code:
 
TAR-TN5431
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN5431-5mg5mg£1,372.00
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Quantity:
TAR-TN5431-1mL1 mL * 10 mM (in DMSO)£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside E4 has anti-injurious, antioxidant, anti-Alzheimer's and anti-inflammatory effects and inhibits SREBP-1c, liver X receptor-α (LXR) and FASN in Icariside E4 is an effective candidate for the treatment of fatty liver disease and has hypolipidemic potential in HepG1 cells.
CAS:
126253-42-7
Formula:
C26H34O10
Molecular Weight:
0
Pathway:
Chromatin/Epigenetic|PI3K/Akt/mTOR signaling|Metabolism|oxidation-reduction
Purity:
0.98
SMILES:
COc1cc(CCCO)cc2[C@@H](CO)[C@@H](Oc12)c1ccc(O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)c(OC)c1
Target:
Liver X Receptor|Lipid|Fatty Acid Synthase|AMPK|Antioxidant

References

Hong EY, et al. Inhibitory Effects of Roseoside and Icariside E4 Isolated from a Natural Product Mixture (No-ap) on the Expression of Angiotensin II Receptor 1 and Oxidative Stress in Angiotensin II-Stimulated H9C2 Cells. Molecules. 2019 ; 24(3):414. Joo T, et al. Inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells by stem bark of Ulmus pumila L. Saudi J Biol Sci. 2014 ; 21(5):427-435. Ferreira-J?nior JC, et al. Isolation of a dihydrobenzofuran lignan, icariside E4, with an antinociceptive effect from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark. Arch Pharm Res. 2015 ; 38(6):950-956. Suh JY, et al. Hypolipogenic effects of Icariside E4 via phosphorylation of AMPK and inhibition of MID1IP1 in HepG2 cells. Phytother Res. 2023 ; 37(1):7-14.