cAC 253
Code | Size | Price |
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TAR-TP2135-5mg | 5mg | £642.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
CAS:
TP2135
Formula:
C126H202N42O40S2
Molecular Weight:
3009.36
Purity:
0.98
SMILES:
0
References
Soudy et al (2016) Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. (N Y) 3 44 PMID: 29067318
Mietlicki-Baase (2018) Amylin in Alzheimer's disease: Pathological peptide or potential treatment? Neuropharmacology 136 287 PMID: 29233636