Goralatide
| Code | Size | Price |
|---|
| TAR-TP2339-5mg | 5mg | £425.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.
CAS:
120081-14-3
Formula:
C20H33N5O9
Molecular Weight:
487.51
Purity:
0.98
SMILES:
CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(O)=O
References
Wierenga PK, Konings AW. Goralatide (AcSDKP) selectively protects murine hematopoietic progenitors and stem cells against hyperthermic damage. Exp Hematol. 1996 Feb;24(2):246-52. PubMed PMID: 8641348.
Li Z, Lebedyeva IO, Golubovskaya VM, Cance WG, Alamry KA, Faidallah HM, Dennis Hall C, Katritzky AR. Synthesis and bioactivity of a Goralatide analog with antileukemic activity. Bioorg Med Chem. 2015 Aug 1;23(15):5056-60. doi: 10.1016/j.bmc.2015.04.061. Epub 2015 May 14. PubMed PMID: 26048023.
Bogden AE, Moreau JP, Gamba-Vitalo C, Deschamps de Paillette E, Tubiana M, Frindel E, Carde P. Goralatide (AcSDKP), a negative growth regulator, protects the stem cell compartment during chemotherapy, enhancing the myelopoietic response to GM-CSF. Int J Cancer. 1998 Mar 30;76(1):38-46. PubMed PMID: 9533760.
Li Z, Lebedyeva I, Zhao D, Myers L, Pillai GG, Hall CD, Katritzky AR. Synthesis of L-Lys-Aminoxy-Goralatide. J Pept Sci. 2014 Dec;20(12):923-7. doi: 10.1002/psc.2702. Epub 2014 Oct 20. PubMed PMID: 25331328.