AZ505

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TargetMol
Product Code: TAR-TQ0100
Supplier: TargetMol
CodeSizePrice
TAR-TQ0100-1mg1mg£124.00
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TAR-TQ0100-2mg2mg£148.00
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TAR-TQ0100-5mg5mg£201.00
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TAR-TQ0100-1mL1 mL * 10 mM (in DMSO)£262.00
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TAR-TQ0100-10mg10mg£282.00
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TAR-TQ0100-25mg25mg£429.00
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TAR-TQ0100-50mg50mg£598.00
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TAR-TQ0100-100mg100mg£821.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
CAS:
1035227-43-0
Formula:
C29H38Cl2N4O4
Molecular Weight:
577.55
Pathway:
Chromatin/Epigenetic
Purity:
0.9848
SMILES:
Oc1ccc(CCNCCN(C2CCCCC2)C(=O)CCNCCc2ccc(Cl)c(Cl)c2)c2OCC(=O)Nc12
Target:
Histone Methyltransferase

References

Komatsu S, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015 Jan 20;112(2):357-64. Ferguson AD, et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.