Pemetrexed disodium
Code | Size | Price |
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TAR-T0189L-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0189L-50mg | 50mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0189L-100mg | 100mg | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0189L-200mg | 200mg | £144.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed therapy has been associated with moderate rates of serum enzyme elevations during therapy, but has not been convincingly linked to instances of acute, clinically apparent liver injury.
CAS:
150399-23-8
Formula:
C20H19N5Na2O6
Molecular Weight:
471.381
Pathway:
Metabolism; Autophagy; DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Apoptosis
Purity:
0.9992
SMILES:
[Na+].[Na+].Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c2c(=O)[nH]1
Target:
Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy
References
1. Shih C, et al. Cancer Res. 1997, 57(6), 1116-1123.
2. Iwahori K, et al. Int J Cancer. 2012, doi: 10.1002/ijc.27611.
3. Teicher BA, et al. Clin Cancer Res. 2000, 6(3), 12016-1023.