Clofarabine

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TargetMol
Product Code: TAR-T0297
Supplier: TargetMol
CodeSizePrice
TAR-T0297-5mg5mg£99.00
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TAR-T0297-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0297-10mg10mg£114.00
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Quantity:
TAR-T0297-25mg25mg£140.00
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Quantity:
TAR-T0297-50mg50mg£179.00
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Quantity:
TAR-T0297-100mg100mg£211.00
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TAR-T0297-200mg200mg£253.00
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TAR-T0297-500mg500mg£375.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
CAS:
123318-82-1
Formula:
C10H11ClFN5O3
Molecular Weight:
303.68
Pathway:
Cell Cycle/Checkpoint; Autophagy; DNA Damage/DNA Repair; Apoptosis
Purity:
1
SMILES:
Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
Target:
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy

References

1. Bonate PL, et al. Nat Rev Drug Discov, 2006, 5(10), 855-863. 2. Yamauchi T, et al. Clin Cancer Res, 2001, 7(11), 3580-3589. 3. Cooper T, et al. Cancer Chemother Pharmacol, 2005, 55(4), 361-368.