Zinc Protoporphyrin
| Code | Size | Price |
|---|
| TAR-T13396-10mg | 10mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.
CAS:
15442-64-5
Formula:
C34H32N4O4Zn
Molecular Weight:
626.03
Pathway:
Metabolism; Apoptosis; NF-κb; Immunology/Inflammation
Purity:
0.9927
SMILES:
CC1=C(C=C)C2=CC3=[N]4C(=CC5=C(C)C(CCC(O)=O)=C6C=C7C(CCC(O)=O)=C(C)C8=[N]7[Zn++]4([N-]2C1=C8)[N-]56)C(C=C)=C3C
Target:
Apoptosis; Reactive Oxygen Species; Endogenous Metabolite
References
1. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4).
2. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229.
3. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197.