TargetMol

GPNA hydrochloride

Product Code:
 
TAR-T15411
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15411-10mg10mg£105.00
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TAR-T15411-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T15411-25mg25mg£133.00
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TAR-T15411-50mg50mg£177.00
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TAR-T15411-100mg100mg£217.00
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TAR-T15411-500mg500mg£439.00
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Further Information

Bioactivity:
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.
CAS:
67953-08-6
Formula:
C11H14ClN3O5
Molecular Weight:
303.7
Pathway:
; Apoptosis
Purity:
0.9991
SMILES:
Cl.N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
Target:
Apoptosis;

References

1. Corti A, et al. ?-Glutamyltransferase enzyme activity of cancer cells modulates L-?-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.