TargetMol

Rottlerin

Product Code:
 
TAR-T16791
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16791-5mg5mg£99.00
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TAR-T16791-10mg10mg£115.00
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TAR-T16791-25mg25mg£165.00
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Further Information

Bioactivity:
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,?,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
CAS:
82-08-6
Formula:
C30H28O8
Molecular Weight:
516.546
Pathway:
; Chromatin/Epigenetic; Cytoskeletal Signaling; Autophagy; Tyrosine Kinase/Adaptors; Microbiology/Virology; Apoptosis; Neuroscience; Proteases/Proteasome
Purity:
0.9741
SMILES:
CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(C(=O)C=Cc3ccccc3)c2O)c1O
Target:
CaMK; Apoptosis; HIV Protease; PKA; PKC; Autophagy

References

1. Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8. 2. Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77(6):460-70. 3. Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.