Belinostat
Code | Size | Price |
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TAR-T1852-5mg | 5mg | £102.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-10mg | 10mg | £120.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-1mL | 1 mL * 10 mM (in DMSO) | £125.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-25mg | 25mg | £149.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-50mg | 50mg | £189.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-100mg | 100mg | £245.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-200mg | 200mg | £349.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1852-500mg | 500mg | £535.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
CAS:
414864-00-9
Formula:
C15H14N2O4S
Molecular Weight:
318.35
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9993
SMILES:
ONC(=O)C=Cc1cccc(c1)S(=O)(=O)Nc1ccccc1
Target:
HDAC
References
1. Plumb JA, et al. Mol Cancer Ther, 2003, 2(8), 721-728.
2. Buckley MT, et al. J Transl Med, 2007, 5:49.
3. Qian X, et al. Mol Cancer Ther, 2006, 5(8), 2086-2095.
4. Chowdhury S, et al. J Biol Chem, 2011, 286(35), 30937-30948.
5. Duan J, et al. Mol Cancer Ther, 2007, 6(1), 37-50.
6. Zuo Y, Xu H, Chen Z, et al. 17?AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA?MB?231 breast cancer cells[J]. Oncology Reports. 2020, 43(6): 1928-1944.