TargetMol

Stampidine

Product Code:
 
TAR-T24839
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24839-5mg5mg£337.00
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TAR-T24839-50mg50mg£1,500.00
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TAR-T24839-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical HIV isolates, non-nucleoside RT-resistant HIV-1 isolates.
CAS:
217178-62-6
Formula:
C20H23BrN3O8P
Molecular Weight:
544.295
Purity:
0.98
SMILES:
COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H](C=C1)n1cc(C)c(=O)[nH]c1=O)Oc1ccc(Br)cc1

References

1. Uckun FM, Cahn P, Qazi S, D'Cruz O. Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS. Expert Opin Investig Drugs. 2012 Apr;21(4):489-500. doi: 10.1517/13543784.2012.664635. Epub 2012 Feb 24. Review. PubMed PMID: 22360744. 2. Agrahari V, Meng J, Zhang T, Youan BB. Application of Design of Experiment and Simulation Methods to Liquid Chromatography Analysis of Topical HIV Microbicides Stampidine and HI443. J Anal Bioanal Tech. 2014 Feb;5(1). pii: 180. PubMed PMID: 25767739; PubMed Central PMCID: PMC4354943. 3. D'Cruz OJ, Samuel P, Waurzyniak B, Uckun FM. Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Biol Reprod. 2003 Dec;69(6):1843-51. Epub 2003 Jul 30. PubMed PMID: 12890726. 4. D'Cruz OJ, Uckun FM. Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Fertil Steril. 2004 Mar;81 Suppl 1:831-41. PubMed PMID: 15019817.