Manzamine A
| Code | Size | Price |
|---|
| TAR-T27977-10mg | 10mg | £1,212.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, and decreases tau hyperphosphorylation.
CAS:
104196-68-1
Formula:
C36H44N4O
Molecular Weight:
548.775
Purity:
0.98
SMILES:
[H][C@]12C[C@]34CN5CC[C@@]3([H])C(=C[C@@](O)(CCC=C/CCCC5)[C@]4([H])N1CCCCC=C/2)c1nccc2c3ccccc3[nH]c12
References
1. Pathak RB, Dobson BC, Ghosh N, Ageel KA, Alshawish MR, Saruengkhanphasit R, Coldham I. Synthesis of the tricyclic core of manzamine A. Org Biomol Chem. 2015 Mar 21;13(11):3331-40. doi: 10.1039/c4ob02582b. PubMed PMID: 25647730.
2. Kallifatidis G, Hoepfner D, Jaeg T, Guzm?n EA, Wright AE. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Mar Drugs. 2013 Sep 17;11(9):3500-16. doi: 10.3390/md11093500. Erratum in: Mar Drugs. 2014;12(4):2305-7. PubMed PMID: 24048269; PubMed Central PMCID: PMC3806460.
3. Furusato A, Kato H, Nehira T, Eguchi K, Kawabata T, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Yokosawa H, Tsukamoto S. Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens. Org Lett. 2014 Aug 1;16(15):3888-91. doi: 10.1021/ol5015569. Epub 2014 Jun 26. PubMed PMID: 24967948.
4. Eguchi K, Fujiwara Y, Hayashida A, Horlad H, Kato H, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S. Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo. Bioorg Med Chem. 2013 Jul 1;21(13):3831-8. doi: 10.1016/j.bmc.2013.04.025. Epub 2013 Apr 21. PubMed PMID: 23665143.