4-Hydroxytoremifene
| Code | Size | Price |
|---|
| TAR-T29437-10mg | 10mg | £328.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29437-100mg | 100mg | £1,344.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
4-Hydroxytoremifene is a selective estrogen receptor modulator toremifene active metabolite.
CAS:
110503-62-3
Formula:
C26H28ClNO2
Molecular Weight:
421.97
Purity:
0.98
SMILES:
CN(C)CCOc1ccc(cc1)C(=C(CCCl)c1ccccc1)c1ccc(O)cc1
References
1. Edavana VK, Dhakal IB, Yu X, Williams S, Kadlubar S. Sulfation of 4-hydroxy toremifene: individual variability, isoform specificity, and contribution to toremifene pharmacogenomics. Drug Metab Dispos. 2012 Jun;40(6):1210-5. doi: 10.1124/dmd.111.044040. Epub 2012 Mar 20. PubMed PMID: 22434874; PubMed Central PMCID: PMC3362788.
2. Fan PW, Zhang F, Bolton JL. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides. Chem Res Toxicol. 2000 Jan;13(1):45-52. PubMed PMID: 10649966.
3. Yao D, Zhang F, Yu L, Yang Y, van Breemen RB, Bolton JL. Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones. Chem Res Toxicol. 2001 Dec;14(12):1643-53. PubMed PMID: 11743747.
4. Kangas L. Biochemical and pharmacological effects of toremifene metabolites. Cancer Chemother Pharmacol. 1990;27(1):8-12. PubMed PMID: 2147128.