Carisbamate
| Code | Size | Price |
|---|
| TAR-T30748-50mg | 50mg | £1,026.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30748-100mg | 100mg | £1,669.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CarisbAMate (JNJ-10234094, RWJ 333369, YKP-509) is an antiepileptic drug candidate.
CAS:
194085-75-1
Formula:
C9H10ClNO3
Molecular Weight:
215.63
Purity:
0.98
SMILES:
NC(=O)OC[C@@H](O)c1ccccc1Cl
References
1. Mangubat EZ, Kellogg RG, Harris TJ Jr, Rossi MA. On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model. J Neurosurg. 2015 Jun;122(6):1283-92. doi: 10.3171/2015.1.JNS14946. Epub 2015 Feb 27. PubMed PMID: 25723302.
2. Hadera MG, Faure JB, Berggaard N, Tefera TW, Nehlig A, Sonnewald U. The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium-pilocarpine epilepsy model. J Neurochem. 2014 Oct 26;132(5):532-545. doi: 10.1111/jnc.12977. [Epub ahead of print] PubMed PMID: 25345404.
3. Shim S, El Mansari M, Blier P. Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain. J Pharmacol Exp Ther. 2013 Nov;347(2):487-96. doi: 10.1124/jpet.113.203315. Epub 2013 Aug 28. PubMed PMID: 23986541.
4. Smith T, DiBernardo A, Shi Y, Todd MJ, Brashear HR, Ford LM. Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials. Pain Pract. 2014 Apr;14(4):332-42. doi: 10.1111/papr.12080. Epub 2013 May 22. PubMed PMID: 23692321.