SY-5609

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TargetMol
Product Code: TAR-T36038
Supplier: TargetMol
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TAR-T36038-25mg25mgEnquire
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TAR-T36038-50mg50mgEnquire
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TAR-T36038-1mg1mg£185.00
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TAR-T36038-2mg2mg£240.00
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TAR-T36038-5mg5mg£360.00
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TAR-T36038-1mL1 mL * 10 mM (in DMSO)£407.00
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TAR-T36038-10mg10mg£539.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
SY-5609 is a selective and noncovalent inhibitor of CDK7(KD = 0.065 nM) with antitumor activity and inhibits apoptosis.
CAS:
2417302-07-7
Formula:
C23H26F3N6OP
Molecular Weight:
490.46
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9932
SMILES:
C(F)(F)(F)C=1C(C=2C=3C(NC2)=C(P(C)(C)=O)C(C#N)=CC3)=NC(N[C@H]4CCC(C)(C)NC4)=NC1
Target:
CDK

References

Michael Bradley, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2020093011A1. Jason J Marineau, et al. Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7. J Med Chem. 2021 Nov 2.