Fluphenazine-N-2-chloroethane (hydrochloride)

TargetMol
Product Code: TAR-T36820
Supplier: TargetMol
CodeSizePrice
TAR-T36820-10mg10mg£99.00
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TAR-T36820-25mg25mg£130.00
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TAR-T36820-50mg50mg£169.00
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Quantity:
TAR-T36820-100mg100mg£256.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 μM), which can sensitize cancer cells to TRAIL-induced apoptosis.
CAS:
3892-78-2
Formula:
C22H25ClF3N3S?2HCl
Molecular Weight:
528.9
Purity:
0.98
SMILES:
ClCCN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(C(F)(F)F)C=C4)CC1.Cl.Cl