TargetMol

MI-3454

Product Code:
 
TAR-T39584
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39584-10mg10mg£724.00
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This product comes from: United States.
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Further Information

Bioactivity:
MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC 50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1 -rearranged or NPM1 -mutated leukemia through downregulation of key genes involved in leukemogenesis.
CAS:
2134169-43-8
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Szymon Klossowski, et al. Menin Inhibitor MI-3454 Induces Remission in MLL1 -rearranged and NPM1 -mutated Models of Leukemia. J Clin Invest. 2020 Feb 3;130(2):981-997.