MI-3454
| Code | Size | Price |
|---|
| TAR-T39584-10mg | 10mg | £724.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC 50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1 -rearranged or NPM1 -mutated leukemia through downregulation of key genes involved in leukemogenesis.
CAS:
2134169-43-8
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
Szymon Klossowski, et al. Menin Inhibitor MI-3454 Induces Remission in MLL1 -rearranged and NPM1 -mutated Models of Leukemia. J Clin Invest. 2020 Feb 3;130(2):981-997.